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ALP64506-Recombinant Human Biotinylated CD28 Protein, Fc Tag, Avi Tag

Protein

ALP64506-Recombinant Human Biotinylated CD28 Protein, Fc Tag, Avi Tag

  • Catalog Number ALP64506
  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD28

CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Classic Mycosis Fungoides and Sezary's Disease. Among its related pathways are CD28 co-stimulation and PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and obsolete SH3/SH2 adaptor activity. An important paralog of this gene is CTLA4.Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.

 

Alpha Lifetech can provide Recombinant Protein products. Including various specifications such as 50, 100, and 500ug, this protein product has been purified and passed quality inspection. Scientists from all over the world are welcome to consult

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Product Background

CD28 is a 44-kDa glycoprotein that binds to B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells (APCs). TCR binding in the absence of CD28 ligation results in either apoptosis or a state of ANERGY

Product Specification

Catalog Number

ALP64506

Product Name

Recombinant Human Biotinylated CD28 Protein, Fc Tag, Avi Tag

Alias

CD28 molecule, Tp44

Alternate Names

cd28,cd28 gene,cd28 marker,cd28 protein,cd28 signaling,recombinant cd28,recombinant cd28 protein,human cd28,human cd28 protein,recombinant human cd28

Official Symbol

CD28

Species

Human

Expression Host

HEK293 Cells

Protein Family

Immunoglobulin Superfamily

Product Description

ALP64506 Recombinant Human Biotinylated CD28 Protein, Fc Tag, Avi Tag is produced in HEK293 Cells and the target gene encoding Asn19-Pro152 is expressed with a Fc, Avi tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

20mM Tris-HCl, 150mM NaCl, pH8.0

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Protein Pathways

Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, T cell receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis

Reference

1 Acuto, O., Michel, F., Nature Reviews Immunology, 2003, DOI: 10.1038/nri1260

2 Linsley, P. S., Ledbetter, J. A., Annual Review of Immunology, 1993, DOI: 10.1146/annurev.iy.11.040193.001343

3 Salomon, B., Bluestone, J. A., Annual Review of Immunology, 2001, DOI: 10.1146/annurev.immunol.19.1.225

 

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