Serivisi yo gusesengura imiterere ya Aptamer
Alpha Lifetech imaze imyaka myinshi itanga serivisi zijyanye na adapt, itanga serivise ziterambere zisesengura
TWANDIKIRE01
Serivisi yo gusesengura imiterere ya Aptamer
Alpha Lifetech imaze imyaka myinshi itanga serivisi zijyanye na aptamer, kandi kuri ubu irashobora gutanga gahunda ziterambere ziterambere rya aptamer nka synthesis ya aptamer, kwerekana SELEX, gukurikiranwa cyane, hamwe no gukoresha neza aptamer. Ukurikije ibyiza byuburyo bwa SELEX bwo gusuzuma aptamers, Alpha Lifetech yaguye uburyo bwinshi bwo gusuzuma aptamers.
Iriburiro ryisesengura rya Aptamer
Kugenzura isano
Ibyiza bya aptamer byagenzuwe nubuhanga bujyanye na aptamer ihuza assay. Ingero zirimo Isothermal Titration Calorimetry (ITC), Flow Cytometry (FCM), na Surface Plasmon Resonance (SPR), Microfluidics, nibindi. Ubusabane bwa Aptamer mubusanzwe bugaragazwa no gutandukana guhoraho (KD), ubwinshi bwumubiri bukoreshwa mukugereranya urugero rwo gutandukana kwa molekile muburyo butandukanye. Gutoya agaciro ka KD, niko bihamye urwego rugoye, ni ukuvuga imbaraga zikomeye; Ibinyuranye, uko agaciro ka KD nini, niko bigenda bihindagurika kandi bigoye. Iyi ntambwe nurufunguzo rwo kumenya imikorere ya aptamer, kwemeza gukura kwa aptamer kandi irashobora guhuza na molekile yintego ifitanye isano ryinshi no guhitamo mubikorwa bifatika.
Igishushanyo.1 Inzira yo gukura kwa aptamer. Inkomoko:Kinghorn AB, Fraser LA, 2017.
Kugenzura imikorere
Usibye kugenzura affinity, imikorere ya aptamer igomba kugenzurwa. Ibi birimo kugenzura aptamer itajegajega, umwihariko, hamwe nimikoranire nizindi molekile mubidukikije. Ibisubizo byo kugenzura imikorere bizagira ingaruka ku buryo butaziguye agaciro ka aptamers mubushakashatsi bwa siyanse no mubikorwa byinganda.
Igenzura ryihariye
Ipiganwa rihiganwa: Ubushobozi bwa aptamer guhuza intego runaka isuzumwa imbere yizindi ntego zisa. Niba aptamer ishobora guhuza cyane na molekile yintego itabangamiye izindi molekile, byerekana ko ifite umwihariko.
Ikigeragezo cyo kwambukiranya imipaka: aptamer ihujwe nuruhererekane rwibintu bifitanye isano cyangwa bidafitanye isano kugirango turebe niba bihuza gusa nintego runaka, kugirango tumenye neza umwihariko wabyo.
Kugenzura gushikamye
Igeragezwa rya Nuclease: Aptamers yahuye nubushakashatsi butandukanye bwa nuclease kandi iyangirika ryabo ryaragaragaye. Mugereranije urwego rwo guteshuka kumwanya utandukanye, ubushobozi bwo kurwanya anti-nuclease ubushobozi bwa aptamer burashobora gusuzumwa.
Ikigeragezo cyubushyuhe nigihe gihamye: aptamer yashyizwe mubushyuhe butandukanye nigihe cyigihe kugirango turebe imiterere n'imikorere yayo. Ibi bifasha kumenya ububiko bwiza no gukoresha imiterere ya aptamers.
Kumenyekanisha ibikorwa byibinyabuzima
Uburyo bukwiye busanzwe bwatoranijwe ukurikije intego yihariye yo gukoresha ya nucleic aside aptamer.
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KACHI
Ibyiza bya Aptamer Ibiranga Serivisi Isesengura
Igenzura ryuzuye
Optimized Aptamers hamwe no guhagarara neza
Ubukungu kandi neza. Ibiciro byinshi birushanwe, serivisi nziza
Uburyo butandukanye bwo gusesengura
Impuguke zabanjirije kugurisha hamwe na serivisi zunganira nyuma yo kugurisha
Uburambe bukomeye mubisesengura rya aptamer
Itsinda ryo mu rwego rwo hejuru R&D
Serivise yihariye ya aptamer iranga serivisi zisesengura
Niba ufite ikibazo, nyamuneka twandikire igihe icyo aricyo cyose.
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2018-07-16 
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