Urubuga rwo gusuzuma Aptamer
Ikoranabuhanga ryo gusuzuma Aptamer
Aptamers ni ADN cyangwa RNA ifite umurongo umwe, ishobora kwivanga mu miterere y’ibice bitatu. Buri gice gifite agace ka nyukleotide 20-60 kari iruhande rw’uturere duto twa 5' na 3', kandi agace ka nyukleotide kari gafite imiterere yihariye 1015. Zishobora guhuzwa n’uburyo bwinshi n’uburyo bwihariye bw’uturemangingo twazo, nk’uko biri ku ngirabuzimafatizo. Kuri ubu, byagaragaye ko bifite ubushobozi bwo gukoreshwa mu nzego nyinshi nko kuvura, gusuzuma indwara no gusuzuma indwara, n’ibindi.
Alpha Lifetech ifite uburambe bwinshi mu ikoranabuhanga ryo gusuzuma ligand, rishingiye ku buhanga bwa Exponential Enrichment Ligand System Evolution (SELEX) bwo guhitamo ligand muri vitro. Nyuma y'imyaka myinshi itera imbere, Alpha Lifetech yashyizeho sisitemu yuzuye yo gusuzuma aside nucleic aptamer, ishobora guha abakiriya serivisi zo gusuzuma aside nucleic aptamer nziza (harimo na aptamers za RNA na aptamers za ADN). Hari uburyo bwinshi bwo gusuzuma nka poroteyine, peptides, aside amine, molecule nto, ndetse n'uburyo butandukanye bwo gusuzuma aptamer (nka SELEX ya magnetic bead, SELEX ya cell, gufata SELEX, nibindi). Uburyo bukoreshwa cyane bwo gusuzuma ni ugusuzuma aside magnetic.
Uburyo bwa tekiniki bwo gusuzuma Aptamer Selex
Uburyo bwa SELEX bwo gusuzuma aptamer butangira uhereye ku rufatiro rw'amasomero ya oligonucleotide agizwe na ADN cyangwa RNA. Inzira zo gutoranya no kongera ubushobozi zigerwaho binyuze mu gushyira isomero rya oligonucleotide hamwe na molekile y'ingenzi, gukaraba oligonucleotides zitarimo, gukuraho aptamers zihambiriye, kongera ubushobozi bwa aptamers zihambiriye na PCR kugira ngo habeho isomero ry'inyongera ryo gusuzuma icyiciro gikurikira. Subiramo intambwe zo gufatanya, kugabanya, kugarura, no kongera kongera ubushobozi. Urutonde rwihariye rukungahaye kuri iyi nzira rugaragara nk'aptamers zikomeye muri isomero.

Igishushanyo cya 1. Uburyo bwa tekiniki bwo gusuzuma SELEX
ibyiza bya aside nucleic aptamer
| Ibyiza | Ibisobanuro birambuye |
|---|---|
| Inzira itaziguye | Kwirinda inzira gakondo yo kugerageza inyamaswa no guhitamo mu bubiko bwa "in vitro"; gusuzuma "selex" aptamers" z'uturemangingo tw’ingenzi tudatera ubudahangarwa bw’umubiri, tudatera ubudahangarwa bw’umubiri cyangwa dufite uburozi. |
| Urutonde rugari rw'ibikorwa | Molekile zigomba kuba ari irangi ry’umwimerere, aside amine, poroteyine, antibiyotike, peptides, vitamine, imiti, ndetse n’uturemangingo, indwara zitera indwara, virusi, ingirabuzima fatizo, nibindi. |
| Ubwumvikane Bukomeye | Aptamers zigaragaza ubuhanga n'ubuhanga bwinshi mu gusuzuma molekile zigamije mu buryo bwa vitro. |
| Ituze | Aptameri ni ntoya, zoroshye kuzibona, zishobora kongera gukoreshwa mu gukora, kandi ubushobozi bwazo bushobora kwiyongera binyuze mu gukora no guhindura imiti. Aptameri ntizihinduka mu buryo bwa shimi, zimara igihe kirekire kandi zishobora gutwarwa ku bushyuhe bw'icyumba. |

Isesengura ry'Ubuzima
Koresha aptamers nk'ibikoresho by'ubushakashatsi cyangwa ibintu by'ibinyabuzima kugira ngo ukore ubushakashatsi ku ngirabuzimafatizo z'ibinyabuzima, gufata amashusho y'uturemangingo n'ubundi bushakashatsi ku isesengura ry'ubuzima.

Gusuzuma indwara
Tegura uburyo bwo gupima indwara bwihuse cyane bushingiye ku mikoranire yihariye ya aptamers na molecules.

Ubushakashatsi ku Buvuzi
n'Iterambere
Koresha aptamer yatoranijwe nk'udukoko tw'imiti cyangwa nk'abatwara imiti kugira ngo ukore imiti mishya yibandwaho.
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