Membrane Poroteyine

Alpha Lifetech yashyizeho serivisi yuzuye yo kwerekana poroteyine, kweza poroteyine, no kwemeza imikorere. Dufite uburambe bukomeye muburyo bwihariye bwa recombinant protein imvugo hamwe na protein imvugo yo kweza. Twateguye neza ibihumbi byinshi bya poroteyine za recombinant kubakiriya bacu, harimo antibodiyite za recombinant, proteine zasohotse, poroteyine za transembrane, protease, nibindi, hamwe niterambere ryinshi.

Gushyira mu bikorwa no gutondekanya poroteyine za Membrane

Ukurikije aho biherereye, poroteyine zigabanyijemo poroteyine zo mu nda, poroteyine za membrane, na poroteyine zidasanzwe. Muri byo, poroteyine za membrane zigera kuri 30% za gen zigizwe na kodegisi zose kandi zigira uruhare runini mubikorwa byubuzima bwa selile. Iyo imikorere ya poroteyine ya membrane idasanzwe, irashobora gutuma habaho indwara zitandukanye. Kurugero, mugihe imvugo yerekana imiterere yo gukura kwa pitoito hamwe na epidermal growth factor reseptor 2 (HER2) hejuru ya selile iba hejuru, irashobora gutera ikwirakwizwa ridasanzwe ryimikorere no gutandukana, ndetse bikanatera kanseri. Guhuza molekile yibiyobyabwenge na proteyine za membrane akenshi bifitanye isano nuburyo bwo gufata ibiyobyabwenge. Kubwibyo, ubushakashatsi ku miterere n'imikorere ya poroteyine ya membrane birashobora gutanga ibitekerezo bimwe byo guteza imbere ibiyobyabwenge. Mugusobanukirwa imikoranire hagati yibiyobyabwenge na proteyine za membrane, ibikorwa byibiyobyabwenge birashobora kunozwa kandi ingaruka mbi zirashobora kugabanuka. Poroteyine za Membrane zirashobora kandi kuba intego yo gufata ibiyobyabwenge, bityo zikaba zishobora gukoreshwa mu kuvura indwara zitandukanye nka kanseri n'indwara z'umutima-damura zibangamira imikorere ya poroteyine. Poroteyine za Membrane zirashobora kumenya neza ibintu bigenewe. Ukurikije ubwo bushobozi bwihariye bwo kumenyekanisha, poroteyine zo mu bwoko bwa membrane zirashobora kuba igice cyingenzi cya biosensor, zibafasha kumenya neza kandi neza ibintu bitandukanye imbere ndetse no hanze yumubiri, harimo ibiyobyabwenge, imisemburo, bagiteri, na virusi.

Poroteyine za Membrane zigabanyijemo ibyiciro bitatu, harimo poroteyine zo mu bwoko bwa periferique, poroteyine zihuriweho hamwe na poroteyine za lipide.

Igishushanyo 1 Imiterere ya poroteyine za membrane no kugenzura lipide.(Inkomoko y'ishusho: Gukurikirana Membrane Protein Dynamics mugihe nyacyo - PMC (nih.gov))

intungamubiri za poroteyine

Poroteyine zo mu bwoko bwa periferique zerekeza kuri poroteyine zishonga mu mazi zihuza na molekile ya poroteyine cyangwa molekile ya lipide ya membrane hejuru ya membrane ikoresheje imigozi ya ionic cyangwa izindi ntege nke zidasanzwe. Izi poroteyine zikwirakwizwa cyane cyane imbere yimbere yimbere kandi zifite imbaraga nke zo guhuza hamwe na membrane. Kubwibyo, mugihe cyose ionic imbaraga zumuti zahinduwe cyangwa ubushyuhe bwiyongereye, proteine za periferique membrane zizatandukana na membrane, bigatuma kweza poroteyine byoroshye.

Intungamubiri za poroteyine

Intungamubiri za poroteyine zerekeza kuri poroteyine zikorana na membrane binyuze mu mikoranire ikomeye ya hydrophobique, bityo igashyiramo neza cyangwa ikinjira muri membrane yose. Bitewe nubushobozi bwabo bwo gukora transembrane helices muri membrane, izo poroteyine zihuza cyane na membrane kandi ntizishobora gushonga mumazi. Intungamubiri za poroteyine zuzuye, zizwi kandi nka poroteyine zo mu bwoko bwa transembrane, zishobora kugabanywa mu ndangagitsina zidasanzwe, indangarubuga ya transembrane, hamwe na domeni idasanzwe. Indangantego ya transembrane isanzwe igizwe na alpha helices, ni igice cya hydrophobique ikorana numurizo wa hydrophobique umurizo wa molekile ya membrane kandi igashyirwa muburyo bwiza. Kwishyira hamwe kwa poroteyine za membrane bigira ingaruka zikomeye kumiterere yimiterere.

Lipid anchored membrane proteins

Lipid anchored membrane proteins bivuga poroteyine zihuza na molekile ya lipide binyuze mu miyoboro ya covalent hamwe na ankor kuri cytoplasmeque. Poroteyine za Lipide zometse kuri lipide zirashobora kuba kuruhande rwimbere ninyuma ya membrane, kandi guhuza kwayo kuribwo birahagaze neza.

Serivisi ifitanye isano

Alpha Lifetech yashyizeho serivise yuzuye ihuriweho na poroteyine, kweza, no kwemeza imikorere.

Serivisi yo kwerekana poroteyine

Serivise ya poroteyine ya Alpha Lifetech itanga ibisubizo bigezweho kugirango habeho poroteyine zitoroshye, harimo GPCR, imiyoboro ya ion, hamwe na virusi zisa na virusi.

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Serivisi yo kweza poroteyine

Alpha Lifetech izahitamo uburyo bwo kweza ukurikije ibyo abakiriya bacu bakeneye, kandi ubihuze hamwe na porogaramu yo kweza poroteyine kugirango tubone ibicuruzwa byiza bya poroteyine nziza mu gihe gito.

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