Urubuga rwo gusuzuma isomero rya Phage Display Peptide

Alpha Lifetech ifite uburambe bwinshi mu kubaka no gusuzuma isomero rya peptide phage, itanga inkunga ikomeye mu buhanga mu kuvumbura imiti mito, gusuzuma indwara, kuvura indwara no gukora ubushakashatsi ku binyabuzima. Dufite abashakashatsi bize cyane kandi b'inararibonye mu gusuzuma isomero rya peptide display, tumaze imyaka icumi twibanda ku kubaka no gusuzuma isomero rya peptide phage, kandi twasuzumye peptide zifite ikoreshwa mu buvuzi ku bakiriya benshi ku isi, aho abarenga 98% bafite umwihariko n'ubuhanga bwinshi, ibyo bikaba byarafashije cyane mu guteza imbere urwego rw'ubuvuzi ku isi.

Peptide zisuzumwe hakoreshejwe ikoranabuhanga rya phage display library zifite ubufatanye bukomeye kandi zishobora kwihuza by'umwihariko na poroteyine zigamije. Byongeye kandi, uburyo bwo gusuzuma peptide bwakozwe mbere bufite ibyiza byo kugabanuka k'umusaruro no gukora igihe gito. Ibyiza bya peptides, nk'uturemangingo duto, kwinjira cyane mu ngingo, kuguma neza, ubushobozi buke bwo kwirinda indwara no kuvura kanseri, bituma zikoreshwa cyane mu kuvumbura imiti, gutegura urukingo, gusuzuma no kuvura kanseri, ubushakashatsi ku nzira z'uturemangingo n'izindi nzego z'ubuvuzi.

Ubwoko bw'isomero rya peptide yerekana phage

Alpha Lifetech yiyemeje guteza imbere gahunda zo kubaka isomero rya peptide display na gahunda zo gusuzuma abakiriya bacu ku isi yose kugira ngo barebe ko imiterere y’ibice by’ingenzi bya peptide ipimwa mu gihe runaka. Dushobora gutanga amasomero ya peptide ya linear, amasomero ya peptide ya cyclic n’andi masomero ya peptide ya randomized arimo aside amine 5-25., kandi amasomero yacu ya peptide phage display afite ubushobozi bwo gusuzuma isomero burenga 10^9, ibyo bikaba byorohereza cyane mu gusuzuma imiterere myiza ya peptide kugira ngo ihuze n’ibyo abakiriya bacu bakeneye. Kugeza ubu, twashoboye kubaka amasomero ya peptide ya linear 7, amasomero ya peptide ya linear 9, amasomero ya peptide ya linear 10, amasomero ya peptide ya linear 15, amasomero ya peptide ya linear 12, amasomero ya peptide ya cyclic 7, n’andi masomero ya peptide afite ingano n’imiterere bitandukanye bya aside amine, kugira ngo duhuze ibyo abahanga mu bya siyansi hirya no hino ku isi bakeneye.

Isomero rya peptide ya phage itandukanye

Isomero ryacu rya peptide rikubiyemo peptide zigororotse, peptide zizenguruka, na peptide zahinduwe kugira ngo harebwe ko intego zikwirakwizwa cyane kandi zitandukanye. Ubwoko bw'isomero burahindagurika kandi butandukanye, bushobora guhaza ibyifuzo byo guteza imbere imiti, kuvumbura ibimenyetso byo gusuzuma no gusuzuma peptide imikorere.

Uburyo bwo gusuzuma hakoreshejwe ubwenge

Hindura ingamba zo gusuzuma ukurikije imiterere y'ikintu kigamije, hamwe no gusuzuma ibice bikomeye, gusuzuma ibice by'amazi n'isuzuma ry'uturemangingo kugira ngo urebe ko ari umwihariko kandi ko ari ingenzi cyane.Gusuzuma no kunoza imiterere y'ibinyabutabire byinshi, gufata neza peptides zifite agaciro kanini.

Igenzura n'ivugurura rinoze

Gukoresha ikoranabuhanga rya "high-throughput sequencing" na "bioinformatics" kugira ngo byihuse ufunge umurongo ngenderwaho, kunoza ibisubizo byo gusuzuma, no kuzigama igihe n'ikiguzi by'ubushakashatsi n'iterambere.

Ubufasha bwa serivisi zuzuye

Gutanga igisubizo kimwe kuva ku kubaka isomero rya peptide kugeza ku igenzura rikurikiraho kugira ngo bishyigikire iterambere ry’imiti n’ubushakashatsi ku mikorere ya molekile.

Uburyo bwo gusuzuma isomero rya Peptide rya Phage Display

gusuzuma isomero rya peptide - Alpha Lifetech

Igishushanyo cya 1 Urubuga rwo gusuzuma isomero rya Peptide Display

Imikorere yo gusuzuma isomero rya Phage Display Peptide

Inzira	Ibikubiye muri serivisi	Ingengabihe
1. Guhagarika ibikorwa by'ishuri no gushyiramo Peptide Library	Molekile zigamije (nk'amaporoteyine, abasirikari b'umubiri cyangwa selile) zihagarara ku bintu bitwara ibintu bikomeye kandi zigashyirwa hamwe na phage mu bubiko bw'ibitabo bya peptide kugira ngo zifatanye na peptide runaka ku kintu kigamije.	Umunsi umwe
2. Gukemura no Kongera Ubukungu	Uduce duto tw’imitsi duto twakuweho hakoreshejwe pH nkeya no gupima ubushobozi bwa molekile, maze uduce duto tw’imitsi duto twongerwamo imbaraga.	Umunsi umwe
3. Inzira yo Gusuzuma	Nyuma y’isuzuma ry’inshuro 3-4, uburyo bwo gusuzuma ibintu buhamye bwagiye burushaho kunozwa buhoro buhoro, kandi imiterere y’ibice byatoranijwe ku ntego yariyongereye.	Icyumweru kimwe
4. Isesengura ry'uruhererekane rwa Peptide	Ingufu zikungahaye zasesenguwe hakoreshejwe uburyo bwo gusesengura imiterere y’ibice bya peptide kugira ngo habeho uburyo bwiza bwo gusesengura imiterere y’ibice bya peptide.	Icyumweru kimwe