Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein related to the cause of disease. The focus of the target began with focusing on tumors and then began to spread to various fields. Introduction to  Siglec-10 is a common target in medicine.

Siglec-10 (sialic acid-binding immunoglobulin-like lectin 10) is a protein that plays an important role in the immune system, and the full-length Siglec-10 protein has a molecular weight of about 68-80 kDa. Siglec-10 is a single-channel transmembrane protein whose extracellular domain contains one V-set Ig-like domain and three C2-set domains, and the cytoplasmic domain contains an immunoreceptor tyrosine-based inhibitor motif (ITIM). Siglec-10 is ubiquitously expressed in immune cells, including a subset of monocytes, eosinophils, B cells, and NK cells. Moreover, its expression can be detected in tissues such as lymph nodes, lungs, ovary, and appendix.

CD24 on the cell surface binds to another membrane protein, Siglec-10, activating immunosuppressive signaling mediated by the SHP-1 / SHP-2 phosphatase. These phosphatases are closely associated with the immune receptor tyrosine repression motif (ITIM) in the Siglec-10 intracellular segment. By blocking the CD24 / Siglec-10 signaling pathway, it accurately regulates the CD24 protein degradation and partially restores the phagocytosis of tumor cells by macrophages. Tumor-associated macrophages express high levels of Siglec-10, and Siglec-10 and CD24 can interact with innate immune cells to mitigate the inflammatory response to a variety of diseases. Inhibition of inflammation caused by SHP-1 and/or SHP-2 phosphatases as well as cytophagocytosis by macrophages, and binding of CD24 to Siglec-10 prevented toll-like receptor-mediated inflammation.

Currently, various immune drugs targeting Siglec-10 targets are in the updating iteration, and taking the disease alone or in combination with other products has become a new approach with remarkable achievements. The Siglec-10 targets have shown important research value and application prospects in both biology and drug research and development. With further research and detection technology advances, Siglec-10 target products are also essential in medical research. Alpha Lifetech can provide Siglec-10 with corresponding products and help each customer's research and development. In addition, Alpha Lifetech also provides advanced expression systems and purification services to accelerate antibody research and development. Our synthesized antibody expression undergoes rigorous quality validation, including sequencing validation and functional expression analysis, to ensure high fidelity and performance. In addition, Alpha Lifetech provides customized solutions for recombinant proteins, such as codon optimization, promoter selection, and vector design, supplemented by downstream applications such as protein expression analysis to meet specific experimental needs.