TNFSF18/GITRL
Alpha Lifetech can provide TNFSF18/GITRL corresponding products, help each customer's research and development.
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Introduction To TNFSF18/GITRL
Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein, which is related to the cause of disease. The focus of the target began with focusing on tumors and then began to spread to various fields. Introduction to TNFSF18/GITRL protein is a common target in medicine.
GITRL, the GITR ligand, also known as TNFSF18, is a specific binding molecule for the glucocorticoid-induced tumor necrosis factor receptor (GITR), also a member of the tumor necrosis factor receptor superfamily (TNFRSF), and GITRL is a type 2 transmembrane protein. It is generally considered as a trimer, although it can also exist as a monomer or assemble into other multimeric forms. GITRL is mainly expressed by activated antigen-presenting cells, including macrophages, B cells, dendritic cells, and endothelial cells.
Function of Target TNFSF18/GITRL
GITRL is similar to OX 40 L and is very highly expressed mainly on activated antigen-presenting cells (APC) and endothelial cells. When GITRL is bound to GITR, it signals through a complex containing a single TRAF 5 and two TRAF 2, thereby activating the NF- ΚB and MAPK signaling pathways. This co-stimulatory effect mediated by GITR ultimately enhanced the proliferation and effector function of T cells, in part due to the upregulation of IL-2R α, IL-2, and IFN γ. In addition, GITR activation also protects T cells from activation-induced cell death (AICD) and promotes an increase in memory T cells. GITRL / GITR mainly participates in the occurrence and progression of inflammation-mediated diseases through activating effector T lymphocytes and regulating regulatory T lymphocytes (Treg). Intervention in the GITRL / GITR pathway has the effect of clearing virus and parasitic infections and enhancing the effect of anti-tumor treatment.
Gene Pathway of Target TNFSF18/GITRL
As a specific ligand of GITR, GITRL can either directly bind to GITR or form a soluble extracellular segment associated with GITR after digestion. This binding mode allows GITRL to regulate the function of GITR, which then affects the activation and proliferation of immune cells.
The action of the GITR / GITRL axis on Treg appears to be inhibitory in the short term, while long-term overstimulation in vivo favors the amplification and activation of Treg in mice.GITRL / GITR mainly participates in the occurrence and progression of inflammation-mediated diseases through activating effector T lymphocytes and regulating regulatory T lymphocytes (Treg). Intervention in the GITRL / GITR pathway has the effect of clearing virus and parasitic infections and enhancing the effect of anti-tumor treatment.
Fig 1: GITRL Gene Pathway. (Reference source: Li L, He Y, Liu K, Liu L, Shan S, Liu H, Ren J, Sun S, Wang M, Jia J, Wang P. GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice. Cell Death Dis. 2024 Feb 6;15(2):114.)
Alpha Lifetech Can Provide
At present, various drugs targeting TNFSF18/GITRL are constantly under development, and taking drugs alone or together with other products to treat diseases has become a new method and remarkable achievements have been made. TNFSF18/GITRL protein has shown important research value and application prospects in tumor biology, and drug research and development. With further research and technological advances, TNFSF18/GITRL protein products are also essential. Alpha Lifetech can provide TNFSF18/GITRL with corresponding products and help each customer's research and development. Alpha Lifetech focuses on high-precision detection development and validation services to support drug screening and biosimilar discovery. Our detection methods, including ELISA, cell-based functional testing, and flow cytometry, have undergone rigorous sensitivity, specificity, and reproducibility testing. In addition to testing and development, our team also provides data analysis, scheme optimization, and cross-species reactivity testing to ensure reliable results.
| Catalog Number | Product Name | Product Sizes |
|---|---|---|
| ALP64704 | 50ug,100ug,500ug | |
| ALP64703 | 50ug,100ug,500ug | |
| ALP64694 | 50ug,100ug,500ug | |
| ALP64651 | 50ug,100ug,500ug | |
| ALP64536 | 50ug,100ug,500ug | |
| ADT1531 | 100ug,1mg,5mg | |
Reference
[1] Tian J, Zhang B, Rui K, Wang S. The Role of GITR/GITRL Interaction in Autoimmune Diseases. Front Immunol. 2020 Oct 9;11:588682.
[2] Gan Y, Zhou H, Guo Y, Huang B, Liu H, Wang Z, Li Z, Zhao X, Zhu H, Han Q, Ye H, He J, Wang Q, Li Z, Sun X. A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17 Response in Primary Sjögren Syndrome. Arthritis Rheumatol. 2024 Apr 8
[3] Wang Y, Liao K, Liu B, Niu C, Zou W, Yang L, Wang T, Tian D, Luo Z, Dai J, Li Q, Liu E, Gong C, Fu Z, Li Y, Ding F. GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4+ T cell differentiation. Respir Res. 2021 Feb 8;22(1):46.
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2018-07-16
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